研究業績（2004-2014年）


１．　原著論文　　

Sugihiro Ando, Atsuya Obinata, Hideki Takahashi (2014) WRKY70 interacting with RCY1 disease resistance protein is required for resistance to Cucumber mosaic virus in Arabidopsis thaliana. Physiological and Molecular Plant Pathology 85: 8-14.

Ryosuke Yasaka, Huy D. Nguyen, Simon Y. W. Ho, Sebastian Duchene, Savas Korkmaz, Nikolaos Katis, Hideki Takahashi, Adrian J. Gibbs, Kazusato Ohshima (2014) The temporal evolution and global spread of Cauliflower mosaic virus, a plant pararetrovirus. PLoS ONE 9(1): e85641

Takahashi, H., Nakaho, K., Ishihara, T., Ando, S., Wada, T., Kanayama, Y., Asano, S., Yoshida, S., Tsushima, S. and Hyakumachi, M. (2014) Transcriptional profile of tomato roots exhibiting Bacillus thuringiensis-induced resistance to Ralstonia solanacearum. Plant Cell Reports 33: 99-110.

Hyakumachi, M., Takahashi, H., Matsubara, Y., Someya, N., Shimizu, M., Kobayashi, K. and Nishiguchi, M. (2014) Recent study on biological control of plant diseases in Japan. Journal of General Plant Pathology 79 (in press).

Mohsen Mohamed Elsharkawy, Masafumi Shimizu, Hideki Takahashi, Kouichi Ozaki and Mitsuro Hyakumachi (2013) Induction of Systemic Resistance against Cucumber mosaic virus in Arabidopsis thaliana by Trichoderma asperellum SKT-1. Plant Pathology Journal 29(2) : 193-200.

Hyakumachi, M., Nishimura, M., Arakawa, T., Asano, S., Yoshida, S., Tsushima, S. and Takahashi, H. (2013) Bacillus thuringiensis suppresses bacterial wilt disease caused by Ralstonia solanacearum with systemic induction of defense-related gene expression in tomato. Microbes and Environments 28: 128-134.

Sagor, G.H.M., Liu, T., Takahashi, H., Niitsu, M., Berberich, T. and Kusano, T. (2013) Longer uncommon polyamines have a stronger defense gene-induction activity and a higher suppressing activity of Cucumber mosaic virus multiplication compared to that of spermine in Arabidopsis thaliana. Plant Cell Reports 32:1477–1488.

Keisuke Mase, Nobuaki Ishihama, Hitoshi Mori, Hideki Takahashi, Hironori Kaminaka, Motoichiro Kodama, and Hirofumi Yoshioka (2013) Ethylene-responsive AP2/ERF transcription factor MACD1 participates in phytotoxin-triggered programmed cell death. Molecular Plant-Microbe Interactions 8: 868-879.

Ishihara, T., Mitsuhara, I., Takahashi, H. and Nakaho, K. (2012) Transcriptome analysis in resistant and susceptible cultivars of tomato infected with Ralstonia solanacearum. PLoS One 7: e46763.

Lapin, D., Meyer, R.C., Takahashi, H. and van den Ackerveken, G. (2012) Broad resistance of Arabidopsis C24 to downy mildew is mediated by different combinations of isolate-specific loci. New Phytologist 196: 1171–1181.

Takahashi, H., Shoji, H., Ando, S., Kanayama, Y., Kusano, T., Takeshita, M., Suzuki, M. and Masuta, C. (2012) RCY1-mediated resistance to Cucumber mosaic virus is regulated by LRR domain-mediated interaction with CMV(Y) following degradation of RCY1. Molecular Plant-Microbe Interactions 25: 1171-1185.

Sagor, G.H.M., Takahashi, H., Niitsu, M., Takahashi, Y., Berberich, T. and Kusano, T. (2012) Exogenous thermospermine has an activity to induce a subset of the defense genes and restrict cucumber mosaic virus multiplication in Arabidopsis thaliana. Plant Cell Reports 31: 1227–1232.

Takahashi, H., Kai, A., Yamashita, M., Ando, S., Sekine, K.-T., Kanayama, Y. and Tomita, H. (2012) Cyclic nucleotide-gated ion channel-mediated cell death may not be critical for R gene-conferred resistance to Cucumber mosaic virus in Arabidopsis thaliana. Physiological and Molecular Plant Pathology 79: 40-48.

Elsharkawy, M.M., Shimizu, M., Takahashi, H. and Hyakumachi, M. (2012) Induction of systemic resistance against Cucumber mosaic virus by Penicillium simplicissimum GP17-2 in Arabidopsis and tobacco. Plant Pathology 61: 964–976.

Elsharkawy, M.M., Shimizu, M., Takahashi, H. and Hyakumachi, M. (2012) The plant growth-promoting fungus Fusarium equiseti and the arbuscular mycorrhizal fungus Glomus mosseae induce systemic resistance against Cucumber mosaic virus in cucumber plants. Plant and Soil (in press) (DOI 10.1007/s11104-012-1255-y)

Ikeda, S., Shimizu, A., Shimizu, M., Takahashi, H. and Takenaka, S. (2012) Biocontrol of black scurf on potato by seed tuber treatment with Pythium oligandrum. Biological Control 60: 297–304.

Takenaka, S., Yamaguchi, K., Masunaka, A., Hase, S., Inoue, T. and Takahashi, H. (2011) Implications of oligomeric forms of POD-1 and POD-2 proteins isolated from cell walls of the biocontrol agent Pythium oligandrum in relation to their ability to induce defense reactions in tomato. Journal of Plant Physiology 168: 1972-1979.

Takahashi, H., Sekiguchi, H., Ito, T., Sasahara, M., Hatanaka, N. Ohba, A., Hase, S., Ando, S. and Takenaka, S. (2011) Microbial community profiles in intercellular fluid of rice and their variation during stages of growth. Journal of General Plant Pathology 77: 121-131.

Hong-Gu Kang, Chang-Sik Oh, Masanao Sato, Fumiaki Katagiri, Jane Glazebrook, Hideki Takahashi, Gregory Martin and Daniel F. Klessig (2010) CRT1, a new player in R (resistance) gene-mediated immunity, implicates endosomes in defense signaling. Plant Cell 22: 918-936.

Aoki, K., Yano, Y., Suzuki, A., Kawamura, S., Sakurai, N., Suda, K., Kurabayashi, A., Suzuki, T., Tsugane, T., Watanabe, M., Ooga, K., Torii, M., Narita, T., Shin-i, T., Kohara, Y., Yamamoto, N., Takahashi, H., Watanabe, Y., Egusa, M., Kodama, M., Ichinose, Y., Kikuchi, M., Fukushima, S., Okabe, A., Arie, T., Sato, Y., Yazawa, K., Satoh, S., Omura, T., Ezura, H. and Shibata, D. (2010) Large-scale analysis of full-length cDNAs from the tomato (Solanum lycopersicum) cultivar Micro-Tom, a reference system for the Solanaceae genomics. BMC Genomics 11: 210.

Masunaka, A., Sekiguchi, H., Takahashi, H. and Takenaka, S. (2010) Distribution and expression of elicitin-like protein genes of the biocontrol agent Pythium oligandrum. Journal of Phytopathology 158: 417-426.

Takahashi, H., Hondo, D., Hase, S. and Takenaka, S. (2010) Identification of a protein that interacts with LeATL6 ubiquitin-protein ligase E3 upregulated in tomato treated with elicitin-like cell wall proteins of Pythium oligandrum. Journal of Phytopathology 158: 132-136.

Kawamura, Y., Takenaka, S., Hase, S., Kubota, M., Ichinose, Y., Kanayama, Y., Nakaho, K. and Takahashi, H. (2009) Enhanced defense responses in Arabidopsis induced by the cell wall protein fractions from Pythium oligandrum require SGT1, RAR1, NPR1 and JAR1. Plant Cell Physiology 50: 924–934.

Mitsuya, Y., Takahashi, Y., Berberich, T., Miyazaki, A., Matsumura, H., Takahashi, H., Terauchi, R. and Kusano, T. (2009) Spermine signaling play as significant role in the defense response of Arabidopsis thaliana to cucumber mosaic virus. Journal of Plant Physiology 166: 626-643.

Sagor, G.H.M., Cong, R.-Z., Berberich, T., Takahashi, H., Takahashi, Y. and Kusano, T. (2009) Spermine signaling in defense reaction against avirulent viral pathogen in Arabidopsis thaliana. Plant Signaling & Behavior 4: 1-3.

Igarashi, A., Yamagata, K., Sugai, T., Takahashi, Y., Sugawara, E., Tamura, A., Yaegashi, H., Yamagishi, N., Takahashi, T., Isogai, M., Takahashi, H., Yoshikawa, N. (2009) Apple latent spherical virus vectors for reliable and effective virus-induced gene silencing among a broad range of plants including tobacco, tomato, Arabidopsis thaliana, cucurbits, and legumes. Virology 386: 407-416.

Kawamura, Y., Hase, S., Takenaka, S., Kanayama, Y., Yoshioka, H., Kamoun, S. and Takahashi, H. (2009) INF1 Elicitin activates jasmonic acid- and ethylene-mediated signalling pathways and induces resistance to bacterial wilt disease in tomato. Journal of Phytopathology 157: 287–297.

Masunaka, A., Nakaho, K., Sakai, M., Takahashi, H. and Takenaka, S. (2009) Visualization of Ralstonia solanacearum cells during biocontrol of bacterial wilt disease in tomato with Pythium oligandrum. Journal of General Plant Pathology 75: 281-287.

Sekine, K-T., Kawakami, S., Kubota, M., Ichinose, Y., Shah, J., Kang, H-G., Klessig, D.F. and Takahashi, H. (2008) High-level expression of a virus resistance gene, RCY1 confers extreme resistance to Cucumber mosaic virus in Arabidopsis thaliana.  Molecular Plant-Microbe Interaction 21: 1398-1407.

Ishihara, T., Sekine, K.-T., Hase, S., Kanayama, Y., Seo, S., Ohashi, Y., Kusano, T., Shibata, D., Shah, J. and Takahashi, H. (2008) Overexpression of the Arabidopsis thaliana EDS5 gene enhances resistance to viruses. Plant Biology 10: 451-461.

Kim, B., Masuta, C., Matsuura, H., Takahashi, H. and Inukai, T. (2008) Veinal necrosis induced by Turnip mosaic virus infection in Arabidopsis is a form of defense response accompanying HR-like cell death. Molecular Plant-Microbe Interactions 21: 260-268.

Takenaka, S., Sekiguchi, H., Nakaho, K., Tojo, M., Masunaka, A. and Takahashi, H. (2008) Colonization of Pythium oligandrum in the tomato rhizosphere for biological control of bacterial wilt disease analyzed by real-time PCR and confocal laser-scanning microscopy. Phytopathology 98: 187-195.

Hase, S., Takahashi, S., Takenaka, S., Nakaho, K., Arie, T., Seo, S., Ohashi, Y. and Takahashi, H. (2008) Jasmonic acid signaling is required for bacterial wild disease resistance induced by biocontrol agent Pythium oligandrum in tomato. Plant Pathology 57, 870–876.

Hondo, D., Hase, S., Kanayama, Y., Yoshikawa, N., Takenaka, S. and Takahashi, H. (2007) Up-regulation of LeATL6 that encodes a fungal elicitor-responsive ubiquitin ligase induces jasmonic acid-dependent proteinase inhibitor gene expression in tomato. Molecular Plant-Microbe Interactions 20: 72-81.

Mitsuya, Y., Takahashi, Y., Uehara, Y., Berberich, T., Miyazaki, A., Takahashi, H. and Kusano, T. (2007) Identification of a novel Cys₂/His₂-type zinc-finger protein as a component of a spermine-signaling pathway in tobacco. Journal of Plant Physiology 164: 785-793.

Sekine, K.-T., Ishihara, T., Hase, S., Kusano, T., Shah, J. and Takahashi, H. (2006) Single amino acid alterations in Arabidopsis thaliana RCY1 compromise resistance to Cucumber mosaic virus, but differentially suppress hypersensitive response-like cell death. Plant Molecular Biology 62: 669-682.

Takenaka, S., Nakamura, Y., Ono, T., Sekiguchi, H., Masunaka, A. and Takahashi, H. (2006) Novel elicitin-like proteins isolated from the cell wall of the biocontrol agent Pythium oligandrum induce defense-related genes in sugar beet. Molecular Plant Pathology 7: 325-339.

Takahashi, H., Ishihara, T., Hase, S., Chiba, A., Nakaho, K., Arie, T., Teraoka, T., Iwata, M., Tugane, T., Shibata, D. and Takenaka, S. (2006) Beta-cyanoalanine synthase as a molecular marker induced resistance by fungal glycoprotein elicitor and commercial plant activators. Phytopathology 96: 908-916.

Hase, S., Shimizu, A., Nakaho, K., Takenaka, S. and Takahashi, H. (2006) Induction of transient ethylene and reduction in severity of tomato bacterial wilt by Pythium oligandrum. Plant Pathology 55: 537-543.

Kon, T., Hidayat, S.H., Hase, S., Takahashi, H. and Ikegami, M. (2006) The natural occurrence of two distinct begomoviruses associated with DNAβ and a recombinant DNA in a tomato plant from Indonesia. Phytopathology 96: 517-525.

Takahashi, H., Shimizu, A., Arie, T., Rosmalawati, S., Fukushima, S., Kikuchi, M., Hikichi, Y., Kanda, A., Ohnishi, K., Ichinose, Y., Yasuda, C., Kodama, M., Egusa, M., Masuta, C., Sawada, H., Shibata, D., Hori, K. and Watanabe, Y. (2005) Catalog of Micro-Tom tomato responses to common fungal, bacterial and viral pathogens. Journal of General Plant Pathology 71: 8-22.

Uehara, Y., Takahashi, Y., Berberich, T., Miyazaki, A., Takahashi, H., Matsui, K., Ohme-Takagi, M., Saitoh, H., Terauchi, R. and Kusano, T. (2005) Tobacco ZFT1, a transcriptional repressor with a Cys₂/His₂ type zinc finger motif that functions in spermine-signaling pathway. Plant Molecular Biology 59: 433-446.

Zheng, M.S., Takahashi, H., Miyazaki, A., Yamaguchi, K. and Kusano, T. (2005) Identification of the cis-acting elements in Arabidopsis thaliana NHL10 promoter responsible for leaf senescence, the hypersensitive response against Cucumber mosaic virus infection, and spermine treatment. Plant Science 168, 415-422.

Sukamto, Kon T, Hidayat, S.H., Ito, K., Hase, S., Takahashi, H. and Ikegami, M. (2005) Begomoviruses associated with leaf curl disease of tomato in Java, Indonesia. Journal of Phytopathology 153: 562-566.

Takahashi, H., Kanayama, Y., Zheng, M. S., Kusano, T., Hase, S., Ikegami, M. and Shah, S. (2004) Antagonistic interactions between the SA- and JA- signaling pathways in Arabidopsis modulate expression of defense genes and gene-for-gene resistance to Cucumber mosaic virus. Plant Cell Physiology 45: 803-809.

Sekine, K.-T., Nandi, A., Ishihara, T., Hase, S., Ikegami, M., Shah, S. and Takahashi, H. (2004) Enhanced resistance to Cucumber mosaic virus in the Arabidopsis thaliana ssi2 mutant is mediated via an SA-independent mechanism. Molecular Plant-Microbe Interaction 17: 623-632.

Ishihara, T., Sakurai, N., Sekine, K.-T., Hase, S., Ikegami, M., Shibata, D. and Takahashi, H. (2004) Comparative analysis of expressed sequence tags in resistant and susceptible ecotypes of Arabidopsis thaliana infected with Cucumber mosaic virus. Plant Cell Physiology 45: 470-480

２．　著書・総説

高橋英樹・安藤杉尋 (2012) 「有機栽培イネ細胞間隙に由来する微生物の解析と病害防除」有機農業研究者会議2012資料集pp51-55.

高橋英樹・安藤杉尋 (2012)「キュウリモザイクウイルス防御応答におけるNB-LRRタンパク質の機能解析」植物感染生理談話会, 平成24年8月30日〜9月1日, 近江八幡市.

高橋英樹・安藤杉尋 (2012)「キュウリモザイクウイルス防御応答におけるNB-LRRタンパク質の機能解析」平成24年度植物感染生理談話会論文集.竹中重仁•高橋英樹 (2012) 「日本発の抵抗性誘導微生物Pythium oligandrum研究の現状」植物防疫 Vol.66, No.6, 36-40.

安藤杉尋・高橋英樹 (2011)「有機栽培イネ細胞間隙に由来する微生物の解析と病害防除」（Analysis of endophytes from intercellular fluid of organically-grown rice plants and its effect on disease tolerance）土と微生物（Soil Microorganisms）Vol. 65 No. 2, pp. 100～103（2011）

Takahashi, H. and Takenaka, S. (2010) “Defense system induced by elicitin-like proteins of biocontrol agent Pythium oligandrum”. Genome-enabled integration of research in plant-pathogen systems. In 10^th Japan-USA Scientific Seminar (Eds. T. Walpert, T. Shiraishim, K. Akimitsu and J. Glazebrook), APS Press, St Paul, Minnesota, USA (in press).

竹中重仁•出崎里永子•高橋英樹 (2010)「非病原菌Pythium oligandrumを利用した広スペクトル微生物農薬の開発」バイオインダストリー 27: 39-46.

高橋英樹 (2010)「抵抗性発現に関わる遺伝子制御」植物病理学（眞山滋志・難波成任 編）pp224-228, 文英堂

高橋英樹・長谷 修・竹中重仁(2009)「モデル植物トマト：マイクロトムを用いた病害研究の現状と今後の展望」植物防疫 63, 605-607.

高橋英樹・竹中重仁 (2009)「土壌生息菌Pythium oligandrumが生産するエリシチン様タンパク質により誘導される感染防御システムの分子機構」日本農薬学会誌34, 39-341

高橋英樹・竹中重仁 (2009)「遺伝子発現からみた誘導抵抗の全体像」微生物と植物の相互作用 −病害と生物防除−（百町満朗・対馬誠也 編）第2章2-1, pp128-133, ソフトサイエンス社

Takahashi, H. (2008) Study on interaction between Cucumber mosaic virus and host plants at a molecular level. Journal of General Plant Pathology 74: 454-456. 

高橋英樹 (2008) 「キュウリモザイクウイルスー宿主植物の相互作用に関する分子生理学的研究 」日本植物病理学会報 74: 134-136.

高橋英樹 (2007) 「キュウリモザイクウイルス抵抗性におけるシグナル伝達機構」微生物の病原性と植物の防御応答（上田一郎 編著）pp87-98, 北海道大学出版会

増田　税・高橋英樹 (2007)「植物のウイルスに対する防御機構」ウイルス研究の現在と展望　蛋白質核酸酵素（野本明男・西山幸廣 編集）Vol.52, No.10, pp1221-1226, 共立出版

Arie, T., Takahashi, H., Kodama, M. and Teraoka, T. (2007) Tomato as a model plant for plant-pathogen interactions. Plant Biotechnology 24: 135-157.

竹中重仁・高橋英樹 (2007) 「プラントアクティベーター開発につながる生物防除微生物による誘導抵抗性機構」（特集：プラントアクティベーター）植物防疫 61: 559-564.

高橋英樹 (2007) 「植物の誘導抵抗性 −広範な病原体に有効な植物独自の自己防御システム−」 ブレインテクノニュース（生研センター）121: 1-4.

高橋英樹 (2005) 「キュウリモザイクウイルスーシロイヌナズナ系におけるNBS-LRR遺伝子ファミリーの発現・機能解析」平成17年度植物感染生理談話会論文集 −植物・病原体相互反応における特異性決定機構− 41: 41-48.　

Takahashi, H., Sekine, K.-T., Ishihara, T., Hase, S., Ikegami, M. and Shah, J. (2005) “Signal transduction pathways for the resistance response to Cucumber mosaic virus.” Genomic and Genetic Analysis of Plant Parasitism and Defense. In 9^th Japan-USA Scientific Seminar (Eds. S. Tsuyumu, J. Leach, T. Shiraishi and T. Walpert), APS Press, St Paul, Minnesota, USA, pp185-194.

高橋英樹 (2004) 「ウイルス感染に対する宿主応答」 新しい作物保護の展開−バイオサイエンスのかけはし− （羽柴輝良　監修）pp274-284, ソフトサイエンス社

高橋英樹 (2004) 「ウイルスに対する宿主抵抗性」　新版 分子レベルからみた植物の耐病性（島本　功・渡辺雄一郎・柘植尚志　監修）植物細胞工学シリーズ19  pp182-188、秀潤社

高橋英樹 (2004) 「ウイルス感染に対する宿主応答」平成16年度植物感染生理談話会論文集―自他識別と応答のバイオフロンティア― 40: 127-139.